We agree with Chapman et al. that the Common Rule needs revision, particularly regarding the application of artificial intelligence and machine learning (AI/ML) in health research with Indigenous Peoples. Without greater consideration of collective harms in human subjects research, this emerging technology has the capacity to circumvent Indigenous Peoples self-determination as reaffirmed by the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP) and the CARE Principles for Indigenous Data Governance (Collective benefit, Authority to control, Responsibility, Ethics).